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Slide presenting research highlights on DeciSomes, describing them as nanoparticle drug carriers targeting pathogens, with potential use against bacteria, protozoa, helminths, and viruses.
Diagram illustrating the structure of a Dectin-1 receptor-targeted antifungal drug-loaded liposome bound to fungal cell oligosaccharides, showing labeled molecular components.
Diagram comparing untargeted and targeted antifungal liposomes; targeted liposomes bind efficiently to fungal cells, shown in yeast morphology, while untargeted liposomes do not bind effectively.
Fluorescent microscopy image shows DEC1-AmB-LLs binding to A. fumigatus conidia and germ tubes (left), while AmB-LLs show no binding (right). Scale bars represent 5 microns.
Two fluorescence microscopy images compare DEC1-AmB-LLs and AmB-LLs binding to green fungal hyphae, showing more red binding in the DEC1-AmB-LL sample.
Three fluorescent microscopy images showing green DEC2-AmB-LLS binding to red-stained Candida albicans yeast cells, pseudo-hyphae, and hyphae; scale bars at 10 or 20 microns.
Microscopy images showing Cryptococcus neoformans labeled for GXM and DEC2-AmB-LL, demonstrating distinct and overlapping binding patterns.
Dectin-2 coated, DEC2-AmB-LL DectiSomes, bind to the extracellular matrices associated with A. fumigatus conidia, germlings, and hyphae
Side-by-side survival graphs show higher survival in mice with candidiasis or aspergillosis after treatment with DEC2-AmB-LLs compared to AmB-LLs or control.
Four microscopy images compare liposome binding (red) to C. albicans hyphae (green); bar graph quantifies increased binding by DCS12-AmB-LLs and DCS78-AmB-LLs over controls.
Bar graph showing the reduction of Candida albicans metabolic activity by DC-SIGN targeted DectiSomes compared to controls, with statistical significance and fold changes indicated.
Bar graph showing the reduction of Candida albicans metabolic activity by DC-SIGN targeted DectiSomes compared to controls, with statistical significance and fold changes indicated.
Bar graphs comparing kidney and lung fungal burdens in mice, showing reduced CFUs with DCS12-AmB-LLs treatment versus controls in C. albicans and A. fumigatus models.
Slide showing the conclusion that no new antifungal drug or delivery method matches DeciSome efficacy in 20 years; more animal model data needed before clinical trials.
A list of six scientific publications related to DectiSomes research, each with titles, authors, publication details, and corresponding links to PubMed or journal sources.

Professor Richard Meagher
Professor Richard Meagher

Dr. Suresh Ambati
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