Homepage

Slide presenting research highlights on DeciSomes, describing them as nanoparticle drug carriers targeting pathogens, with potential use against bacteria, protozoa, helminths, and viruses.
Diagram illustrating the structure of a Dectin-1 receptor-targeted antifungal drug-loaded liposome bound to fungal cell oligosaccharides, showing labeled molecular components.
Diagram comparing untargeted and targeted antifungal liposomes; targeted liposomes bind efficiently to fungal cells, shown in yeast morphology, while untargeted liposomes do not bind effectively.
Fluorescent microscopy image shows DEC1-AmB-LLs binding to A. fumigatus conidia and germ tubes (left), while AmB-LLs show no binding (right). Scale bars represent 5 microns.
Two fluorescence microscopy images compare DEC1-AmB-LLs and AmB-LLs binding to green fungal hyphae, showing more red binding in the DEC1-AmB-LL sample.
Three fluorescent microscopy images showing green DEC2-AmB-LLS binding to red-stained Candida albicans yeast cells, pseudo-hyphae, and hyphae; scale bars at 10 or 20 microns.
Microscopy images showing Cryptococcus neoformans labeled for GXM and DEC2-AmB-LL, demonstrating distinct and overlapping binding patterns.
Dectin-2 coated, DEC2-AmB-LL DectiSomes, bind to the extracellular matrices associated with A. fumigatus conidia, germlings, and hyphae
Side-by-side survival graphs show higher survival in mice with candidiasis or aspergillosis after treatment with DEC2-AmB-LLs compared to AmB-LLs or control.
Four microscopy images compare liposome binding (red) to C. albicans hyphae (green); bar graph quantifies increased binding by DCS12-AmB-LLs and DCS78-AmB-LLs over controls.
Bar graph showing the reduction of Candida albicans metabolic activity by DC-SIGN targeted DectiSomes compared to controls, with statistical significance and fold changes indicated.
Bar graph showing the reduction of Candida albicans metabolic activity by DC-SIGN targeted DectiSomes compared to controls, with statistical significance and fold changes indicated.
Bar graphs comparing kidney and lung fungal burdens in mice, showing reduced CFUs with DCS12-AmB-LLs treatment versus controls in C. albicans and A. fumigatus models.
Slide showing the conclusion that no new antifungal drug or delivery method matches DeciSome efficacy in 20 years; more animal model data needed before clinical trials.
A list of six scientific publications related to DectiSomes research, each with titles, authors, publication details, and corresponding links to PubMed or journal sources.

 

Professor Richard Meagher

 

Dr. Suresh Ambati